Predictors of 6 month-mortality following intermediate-high and high risk pulmonary embolism

Abstract Funding Acknowledgements Type of funding sources: None. BACKGROUND Pulmonary embolism (PE) is the third most frequent cardiovascular disease and associated with high mortality, during admission short-term follow-up. Due to Right Ventricular (RV) dysfunction or Hypertension (PH), also because anticoagulation's bleeding complications PE may be first manifestation underlying cancer. Purpose To determine clinical echocardiography characteristics 6 month-mortality patients an intermediate-high admitted in Acute Cardiovascular Care Unit (ACCU). Methods The present study a retrospective analysis 137 risk our ACCU between May-2017 May-2021. Clinical, biochemical echocardiographic variables were analyzed on admission, prior discharge month follow-up period. Mortality was evaluated at months. Univariate logistic used analyze markers mortality. Results majority women 77 (56%), aged 16-90 years. 78 (57%) had hypertension, 64(46%) Dyslipemia, 50(37%) obesity 12 (9%) previous On 76( 56%) consulted for dyspnea 52(38%) syncope. 81 (60%) presented respiratory failure (pO2<60 mmHg), 98(72%) elevated Nt-proBNP (3583 ±4874) 109 (80%) Troponin. 36 (27%) Shock Index>1. echocardiography, 90 (66%) RV (TAPSE≤16mm), 120(89%) dilated (basal RV/LV ratio>1.0) PH was: 44 (36%) Mild, 48 (39%) Moderate 22 (18%) Severe. Regarding treatment received: 85 (62%) Heparin Sodium, 11 (8%) Systemic fibrinolysis, 31 (23%) Catheter-directed therapies 10 (7%) LMWH. During (5%) suffer minor 9 major bleeding. At 101 (82%) improved function 95 (None 62 (54 %), Mild 40 (35%), Severe 2 (2%)). In months follow-up, 13(10%) died, 3(2%) readmitted new 4(3%) New cancer diagnosed 12(9%) patients. (74%) NYHA-I. death (Table 1) significantly increased diabetes (46% vs 16%,p=0.009), those which persisted (50% 8%,p=0.001), case readmission (43% 0.8%,p=0.001) (57% 7%,p=0.001). Variables months-mortality univariate 2) are: Nt-proBNP, Major readmission, cancer, discharge, Dilated-RV moderate severe before discharge. Conclusion sample, due PH, persistence dysfunction, having suffering from short increases death. Although data misestimated low rate events.